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250 micrograms (0. harga mefentan 500 mg 25 mg) to 500 micrograms (0 5 mg) three times daily, increasing if required to a total of 3 mg daily The elderly or in the presence of debilitating disease 250 micrograms (0 25 mg) two to three times daily to be gradually increased if needed and tolerated If side-effects occur, the dose should be lowered